Modafinil Dosage Guide- How To Use The Smart Drug Safely And Effectively

Modafinil Dosage Guide- How To Use The Smart Drug Safely And Effectively

Modafinil pill is available in dosage strengths of 100 and 200 mg. The standard dosage of the Nootropic is 200 mg for all the conditions treated by the Nootropic. It comes in tablet form and should be taken with or without food with a glass of water.

Modafinil is a strong central nervous system stimulant that promotes wakefulness and helps in the treatment of sleep disorders.

It is very important to follow the proper dosage for its effectiveness.

This comprehensive guide provides all the recommended dosages of the nootropic for different disorders along with all the necessary guidelines for administering the drug.

What Is Modafinil?

Modafinil is a wakefulness-promoting agent that comes under Schedule IV of the Controlled Substances Act. Developed in the 1970s by Lafon Laboratories and Michel Jouvet, Modafinil was approved in 1998 in the United States for medical purposes.

It is available under the brand names Modvigil, Modalert, and Provigil, which show similar effectiveness and potency as Modafinil. 

Mechanism Of Action Of Modafinil 

Modafinil is a weak dopamine reuptake inhibitor that works by directly functioning in the hypothalamus of the brain. This nootropic helps in the secretion of histamine and dopamine in the body, which aids in wakefulness and improves brain functioning.

Why Is Modafinil Prescribed?

Here is the nitty-gritty of Modafinil's uses.

The U.S. Food and Drug Administration approves Modafinil to treat sleep disorders such as  Narcolepsy, Obstructive sleep apnea, and Shift Work Disorder. It is sold under the brand names Modalert and Modvigil, among others.

Along with its on-label or FDA-approved benefits, Modafinil has numerous off-label benefits as well,  such as it is used in the treatment of attention deficit hyperactivity disorder, acute unipolar and bipolar depressive episodes, cocaine dependence, cancer-related and multiple sclerosis-related fatigue and also as cognitive enhancer. 

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What Are The Dosages Of Modafinil?


The dosages of Modafinil differ from patient to patient. You should only take this medicine under the proper guidance of your doctor. 

The standard dosage for Modafinil is 200 mg. It is suggested for people aged 17 years or older. 

Here is the proper dosage recommended for different disorders. 

Modafinil Dosage for Narcolepsy and Obstructive Sleep Apnea

The recommended dosages of Modafinil for Narcolepsy and Obstructive Sleep Apnea are 200 mg/day. It is generally taken in the morning because this helps a person stay awake, alert, and focused throughout the day [1].

Your health professionals or experts may occasionally advise increasing the dosage to 400 mg per day [2].

Modafinil Dosage for Shift Work Disorder

The suggested dosage of this nootropic for Shift Work Disorder is 200 mg/day. The perfect time to take this drug is to ingest it one hour before your shift work begins [1].

Modafinil Dosage For Off-Label Uses 

Modafinil Dosage For Adhd Or Attention Deficit Hyperactivity Disorder 

The Modafinil dosage for ADHD ranges from 100 mg to 200 mg per day; it is essential to keep in mind that Modafinil is not approved for use in children. Thus, this drug is not recommended for children, even in a low amount [3].

- Modafinil Dosage For Depression 

For depression, the recommended dosage of Modafinil is 200 mg, which should be taken in the morning without exceeding the daily limit of 400 mg. 

- Modafinil Dosage For Cognitive Enhancement 

People frequently use Modafinil for cognitive enhancement, and the dosage range for Modafinil's Cognitive enhancing benefits is 100-200 mg [4]. 

Modafinil Dosage For Cancer And Multiple Sclerosis-Related Fatigue

The recommended dosage of Modafinil for treating cancer and multiple sclerosis-related fatigue is 200 mg [5]. 

What To Do When You Miss A Dose?

Whenever you miss a dose in any circumstance, whether intentionally or accidentally, you should immediately take the dose as soon as you recall it.

If your next dose is approaching, you should skip the missed dose and follow your normal schedule.

Do not overlap the doses; otherwise, it can lead to an overdose. Overdose might be dangerous as it has a lot of health risk factors like- headaches, dizziness, anxiety, etc.

Ingesting Modafinil daily might lead to physical as well as psychological dependence that might lead to Modafinil Abuse. When you use Modafinil for a long time, your body and mind get used to it.  Once you suddenly cut it off, there might be several withdrawal symptoms.

Some of the withdrawal symptoms include Decreased motivation, Sleeping problems, Breathing issues, and a drain on energy levels.

Factors That Affect Modafinil Dosage

Factors affecting the dosage of Modafinil are as follows:


Age may affect Modafinil dosage because, with age, metabolism slows down, affecting the way Modafinil is absorbed.

Liver and Kidney Function

The dosage of Modafinil also depends on your kidney and liver function. Modafinil is taken in low dosages if your kidney or liver is not functioning well. 

Proper Administration Of Modafinil

Below are a few tips on how to take Modafinil properly - 

  • You must swallow the tablet.

  • Do not chew or crush the tablet.

  • Avoid taking it at night. This might cause problems like Insomnia.

  • Take the dosage every day simultaneously to get the maximum benefits.

Precautionary Measures While Administering Modafinil

Various precautionary measures need to be taken while using Modafinil. Some of them are listed below - 

1. Inform your doctor if you are allergic to Modafinil.

2. You should inform your doctor about your medical history if you have any heart disease, breathing problems, high blood pressure, or liver or kidney dysfunction.

3. If you have a family history of alcohol addiction, you should inform your doctor.

4. Avoid activities that require your alertness, like driving.

5. You must completely avoid contraceptives and inform your doctor if you are pregnant.

6. Breastfeeding women should consult their doctor before taking the Nootropic.

Side Effects of Modafinil

Below are some of the side effects that are associated with Modafinil.

  • Headache

  • Dizziness

  • Breathing problems

  • Irrational heartbeat

  • Chills and fever

  • Swollen face, throat, or tongue.

  • Skin rashes, peeling or blistering of the skin

  • Anxiety

  • Confusion

  • Decreased focus.

Modafinil Dosage Guide - Final thoughts

Modafinil is an effective nootropic with various indications, but when you’re taking this nootropic, be sure to take the correct dosage and monitor your use to get the most benefits out of the drug.


The standard recommended dose for Modafinil is 200mg daily with a glass of water.

Modafinil doses can go up to 400mg per day.

The correct time for administering Modafinil is in the morning. You should avoid consuming the tablet at night as it leads to high chances of Insomnia.

Modafinil is a Schedule IV controlled substance under the Controlled Substances Act because it has a high chance of Abuse.

You should consult your health experts or medical professionals before taking Modafinil. It is generally prescribed for treating excessive sleepiness like Narcolepsy, Obstructive Sleep Apnea, or other shiftwork disorders. It also has some off-label uses like depression, anxiety, fatigue, ADHD, etc.

The effect of Soma lasts up to 3-4 hours in Saliva from the intake of Soma dosage.


  1. Modafinil, mayoclinic

  2. Modafinil, referencemedscape.

  3. Modafinil guide recommended dosing, cognitune

  4. Modafinil Dosage Guide: Finding Your Perfect Dose, wholisticresearch

  5. Modafinil in treatment of fatigue in multiple sclerosis. Results of an open-label study, NCBI

Author’s Note

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